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nabumetone, Relafen
GENERIC NAME: nabumetone BRAND NAME: Relafen
DRUG CLASS AND MECHANISM: Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) effective in treating fever, pain, and inflammation in the body. As a group, NSAIDs are non-narcotic relievers of mild to moderate pain of many causes, including injury, menstrual cramps , arthritis , and other musculoskeletal conditions. Since the response to different NSAIDs varies from patient to patient, it is not unusual for a doctor to try different NSAIDs for any given condition.
PRESCRIPTION: yes
GENERIC AVAILABLE: yes
PREPARATIONS: tablets: 500mg, 750mg
STORAGE: Store at room temperature in a sealed, light- resistant container. Avoid moisture.
PRESCRIBED FOR: Nabumetone is used for the treatment of inflammation and pain that results from rheumatoid arthritis and osteoarthritis . Nabumetone has the convenience of once daily dosing.
DOSING: May be taken with or without food.
DRUG INTERACTIONS: Nabumetone should be avoided by patients with a history of asthma exacerbation, hives , or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with peptic ulcer disease or poor kidney function, since this medication can aggravate both conditions. Nabumetone is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of an increased risk of bleeding. Patients taking lithium can develop toxic blood lithium levels. Patients taking cyclosporine (Sandimmune) can develop kidney toxicity.
Use in children has not been adequately studied. Nabumetone is not habit forming. NSAIDs should be discontinued prior to elective surgery because of a mild interference with clotting that is characteristic of this group of medicines. Nabumetone is best discontinued at least two days in advance of the procedure.
Persons who have more than 3 alcoholic beverages per day are at increased risk of developing stomach ulcers when taking nabumetone or other NSAIDs.
PREGNANCY: Nabumetone is generally avoided during pregnancy.
NURSING MOTHERS: Nabumetone is generally avoided in nursing mothers.
SIDE EFFECTS: Most patients benefit from nabumetone and other NSAIDs with few side effects. However, serious side effects can occur, and generally tend to be dose related. Therefore, it is advisable to use the lowest effective dose to minimize side effects. The most common side effects of nabumetone involve the gastrointestinal system. Some studies have shown that nabumetone may have a lower risk of gastrointestinal side effects than the other NSAID medications. However, it can still cause ulcerations, abdominal pain , cramping, nausea, gastritis, and even serious gastrointestinal bleeding and liver toxicity. Sometimes, stomach ulceration and bleeding can occur without any abdominal pain. Black tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding. Rash, kidney impairment, ringing in the ears, and lightheadedness can also occur.
Last updated on 05/15/2008
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